How Do Psychedelics Affect The Brain?


Psychedelics have been around for the longest time, since before we knew what they could do to your body. Ancient civilizations would use a form of hallucinogenic drugs for rituals and religious purposes and would often consider them a necessity in terms of spirituality.

Today Psychedelic drugs are used for various reasons, for partying, having a good time, and even medical reasons, like treating depression or anxiety. Today we will go over these hallucinogenic drugs and how they affect your brain. So stay tuned and keep reading!

READ: Can Psychedelics Treat Anxiety?

What Are Psychedelics?


Psychedelics are some mind-altering substances if we're being technical. Sure, they fit into all kinds of highbrow definitions, but what's important is that these drugs can cause changes in perception and behavior.

Plus, you can use these substances recreationally, medicinally, or spiritually; all of which gives us plenty of choices, so whatever you're into, chances are there's a psychedelic out there waiting for you to take the plunge.

Types of Psychedelics

Most psychedelics are classified by one thing, their ability to alter your perception and make you feel differently than you usually do. Some drugs like Magic mushrooms or LSD are well known for making people see and feel sensations they have never felt before. Some claim to hallucinate; others claim to feel feelings they have never felt before, while other visual disturbances have also been reported.

Here are some of the most common classic hallucinogens.


LSD is a dissociative drug that has been around since the 1950s and is known for its intense trip-like effects. Taking the drug can make you feel dissociated from the world, give you an out-of-body experience, and intensify all positive and negative feelings.

Some people have even reported feeling like they could hear sounds that weren't playback in reality - it certainly shows why LSD has been popular over the decades.


Mescaline is a psychoactive drug that brings about an altered state of mind. It's not quite as potent as its other hallucinogenic drugs, but it can still cause a perception disorder.

Although it can be artificially produced in powder or pill form, more often than not, mescaline is derived from cacti - the most popular of which is peyote. Traditionally, mescaline has been chewed or brewed into tea.

Psilocybin(Magic Mushroom)

magic mushroom

Arguably the most popular items on this list, magic mushrooms are the most common and easiest to get. Effects of shrooms can be minor, like a body high, and minor visual disturbances, and can go extreme, like full-on hallucinations and auditory hallucinations.

Shrooms have also been used in a medical capacity in the past. They may help treat depression and brain function but are considered one of the most common classic dissociative drugs.


PCP is an infamous dissociative drug that alters brain chemistry and messes with brain regions associated with perception, memory, learning, emotion, and motor control. Depending on the amount taken, it can range from producing a stimulating high to an anesthetic effect and is considered a dissociative drug.

Street names include Angel Dust, Supergrass, and Rocket Fuel, all bringing images of out-of-this-world intensity to mind. But the long-term risks of PCP use are no joke; regular users can suffer from persistent psychosis and other mental disorders.


Another well-known hallucinogen and the only legal drug on this list. You can get weed anywhere in the US, and it can often be used for medical reasons like anxiety or depression, and even pain.

Cannabis can have different effects depending on how much you take, how, and what kind of strain you use. Cannabis can be mellow, and even at its highest consumption, the effects are temporary, and very rarely will it have long-term consequences.

READ: What Is Delta 11?


Ecstasy, a serotonin receptor stimulant, is more than just a great name for a rave drug – it's an experience that takes communication to a new level. People under the effect of Ecstasy report enhanced feelings of emotional warmth and increased empathy for others, which has been attributed to its serotonin receptor-invading properties.

Additionally, users receive heightened sensations of pleasure and energy along with distorted sensory and time perceptions. Coupled with the use of this particular drug at nightclubs and all-night dance parties ("raves")


One of the dissociative drugs currently being studied for treating mental and psychological disorders is ketamine. It is one of the dissociative drugs used in human and veterinary medicine that produces a sense of detachment from reality – and not just literally!

While ketamine is mainly obtained from medical professionals, it has been found on the illegal drug market, most likely obtained from hard-working veterinarians' offices. It's even been speculated that its chemical structure and mechanism of action are linked to that of PCP


Used as dissociative drugs in spiritual rituals centuries ago, salvia’s active ingredient—salvinorin A—makes it unique. It's said to be one of the most potent psychoactive drugs, with all kinds of unexpected effects like hallucinations, clarity of thought, and rapid emotional shifts — to name a few.

Salvia is well known in Central America and Mexico for its effects, and the use of Salvia dates back to the Aztec Indians.

How Do Hallucinogens Affect The Brain?

Hallucinogens have been known to profoundly affect the medial prefrontal cortex, interfering with its role in helping us process complicated thoughts, focus our attention, and plan. However, their influence goes beyond the medial prefrontal cortex; hallucinogens can also disrupt other neurotransmitter systems and neural circuits that use serotonin.

All these affected areas are involved in many essential brain functions such as perceiving reality, decision making, and controlling our emotions - so it's no surprise we're seeing such drastic effects of this type of drug.

Psychedelics can give you a mind-altering experience but also cause physical effects. Not only do they interfere with the glutamate levels in your brain, leading to increased energy and neurological disorders, but they can also be a significant cause of physical discomfort.

Users commonly feel like their physical form is contorting and twisting in odd ways -- an effect aptly named dissociation. While some may find it exciting to explore these altered physical states, others might just be left feeling more than a little disoriented and out of place. They all affect the human brain in different ways and can have short- and long-term effects on the body.

Are Psychedelics Legal?

In most countries, psychedelics rarely find themselves on the right side of the law. Cannabis is an exception that can be found legally as a medical prescription and recreational drug in certain states, and mushrooms are making headway toward decriminalization at a rapid pace.

It's almost like psychedelic drugs have finally put down the peace pipe and are starting to understand the law, thanks partly to their many manifold benefits for mental health, creativity, and general well-being.

Where To Find The Best Psychedelics Supplements?

Psychedelics may be illegal, but mushroom supplements are a legal gray area. Supplements will give you a little psychedelic experience, and although it’s not as strong, they can still benefit you greatly.

At, we have partnered with some of the most reputable brands in the industry to provide some of the best mushroom supplements for you to try. With Slyng, you can get discounts and coupon codes to save even more.

READ: Can You Smoke Shrooms?

How Do Psychedelics Affect The Brain? - Conclusion

Psychedelics have been getting a lot of attention in recent years. Some might argue that it’s because we are finally starting to catch up with the 60s and 70s when these drugs first gained popularity. But whether you think Psychedelics are a fad or here to stay, there is no denying that they can have short and long-term effects on those who use them.

The best way to enjoy psychedelics is to do so responsibly and always make sure you do your research before trying any new drug. Thanks for reading!